|
KMID : 0378119850120010060
|
|
Chungnam Medical Journal
1985 Volume.12 No. 1 p.60 ~ p.67
|
|
|
Effect of Lithium on the Electrolyte Excretion of Rabbit
|
|
|
|
|
Abstract
|
|
|
Lithium reabsorption ocrurred in the renal tubule and the lithium and sodium were conserved at that site by the same mechanism. This study was attempted to investigate· the effect of lithiuln on the urinary excretion of elect.olyies and water. physiological saline was infused to hydrate the rabbit and collected the urine and plasma samples for control after reached steady state.
After priming dose of LiCl (2mEq/kg) injected, during infusion of LiCl solution(0.2mEq/kg/hr)urine and plasma samples obtained for observation of Li^(+) effect. And then 2% NaCl(NaCl group) or 0.3M sucrose(sucrose group) solution was infused to evaluate the effect on the renal function with the changes in plasma electrolyte concentration.
The results obtained were summarized as follows :
1. Control urine flow rates in NaCl group was 2.28±0.03m1/10min. During Li^(+) infusion the urine flow rate was increased significantly in both group.
2. Li^(+) induced water diuresis with reduced urinal)· Na^(+) and osmolar conrentration while constant excretion of osmolar particles and Na^(+).
3. Infusion of 2% NaCl solution(with LiCl) persisted the water diuresis instead of increased plasma Na^(+) and osmslar concentration.
4. Infusion of 0.3M sucrose solution also persisted the water diuresis with low plasma Na^(+) and Li^(+) concentration.
5. Plasma Li^(+) concentration was signiiicantly lowered during infusion of sucrose solution that of NaCl infusion.
From the above results, it was suggested that water diuresis by the lithium was affected to ADH action and sucrose solution infusion reduced the effect of Li^(+) on the kidney by the Na^(+)countertransport mechanism with Li^(+).
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|